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Opportunistically Detecting Signs of Hypertension on a Consumer Smartwatch Paolo Di Achille Lawrence Cai Ming-Zher Poh Article 05 Nov 2026 Opportunistically Detecting Signs of Hypertension on a Consumer Smartwatch Paolo Di Achille Hydrogen Derivatives Enable Cost-Effective Carbon Neutrality in China Xinyu Chen Xinyang Guo Michael McElroy Article 05 Nov 2026 Hydrogen Derivatives Enable Cost-Effective Carbon Neutrality in China Michael McElroy Carbon radical generation by irreversible metal-to-ligand charge transfer Zhiqiang Wei Xiang Li Jinbo Hu Article 04 Nov 2026 Carbon radical generation by irreversible metal-to-ligand charge transfer A two-dimensional reticular triaxial molecularly woven fabric A two-dimensional reticular triaxial woven network material is constructed by incorporating C 3 -symmetric macrocycles into a triangular weave pattern, enabling an extra topological dimension to be used for the construction of functional materials. Mengbin Wang Shuai Fang Feihe Huang Article 04 Nov 2026 A two-dimensional reticular triaxial molecularly woven fabric A two-dimensional reticular triaxial woven network material is constructed by incorporating C 3 -symmetric macrocycles into a triangular weave pattern, enabling an extra topological dimension to be used for the construction of functional materials. In vivo CAR-T double knockout screen maps synergistic antitumour gene pairs Using high-throughput in vivo CAR-T double knockout screening, synergistic gene combinations to improve CAR-T cell therapy are revealed. Liqun Zhou Paul A. Renauer Sidi Chen Article 04 Nov 2026 In vivo CAR-T double knockout screen maps synergistic antitumour gene pairs Using high-throughput in vivo CAR-T double knockout screening, synergistic gene combinations to improve CAR-T cell therapy are revealed. Paul A. Renauer Observation of prethermal dynamical phase transitions and resonant melting A programmable neutral-atom quantum simulator is used to explore quench dynamics in spin models with up to 180 qubits, revealing prethermal dynamical phase transitions and resonant melting. Siva Darbha Alexey Khudorozhkov Milan Kornjača Article 04 Nov 2026 Observation of prethermal dynamical phase transitions and resonant melting A programmable neutral-atom quantum simulator is used to explore quench dynamics in spin models with up to 180 qubits, revealing prethermal dynamical phase transitions and resonant melting. Alexey Khudorozhkov Ecological and social cues orchestrate concerted courtship in Drosophila In Drosophila erecta , food odours initiate male sexual arousal, which is subsequently reinforced by the visual motion of other courting flies, creating a multisensory mechanism that synchronizes courtship in groups when conditions are favourable for reproduction. Philipp Brand Katharine Keller Vanessa Ruta Article Open Access 04 Nov 2026 Ecological and social cues orchestrate concerted courtship in Drosophila In Drosophila erecta , food odours initiate male sexual arousal, which is subsequently reinforced by the visual motion of other courting flies, creating a multisensory mechanism that synchronizes courtship in groups when conditions are favourable for reproduction. Katharine Keller An AI-native experimental laboratory for autonomous biomolecular operations AutoDNA is an artificial intelligence (AI)-native autonomous biomolecular engineering laboratory targeting multi-objective experiments across diverse instruments, realizing the co-evolution of AI and the automation system within an end-to-end multi-user framework. Mingyu Wu Zhaoguo Wang Haibo Chen Article 04 Nov 2026 An AI-native experimental laboratory for autonomous biomolecular operations AutoDNA is an artificial intelligence (AI)-native autonomous biomolecular engineering laboratory targeting multi-objective experiments across diverse instruments, realizing the co-evolution of AI and the automation system within an end-to-end multi-user framework. Multimodal X-ray imaging reveals hierarchical fibre mechanics The X-ray visualization platform TomoSAXS, demonstrated here on intervertebral spinal discs, can visualize nanoscale to macroscale mechanics in intact biological organs and fibrous materials. Elis Newham Alissa L. Parmenter Himadri S. Gupta Article Open Access 04 Nov 2026 Multimodal X-ray imaging reveals hierarchical fibre mechanics The X-ray visualization platform TomoSAXS, demonstrated here on intervertebral spinal discs, can visualize nanoscale to macroscale mechanics in intact biological organs and fibrous materials. Alissa L. Parmenter Himadri S. Gupta Towards observing interstitial hydrogen in solution in metal lattices Using deuterium as a proxy for hydrogen, atom probe tomography provides experimental evidence for interstitial hydrogen in solid solution across different FCC phases, consistent with theoretical predictions of hydrogen affinity, revealing hydrogen partitioning in structural alloys. Chao Huang Saiyu Liu Eason Yi-Sheng Chen Article Open Access 04 Nov 2026 Towards observing interstitial hydrogen in solution in metal lattices Using deuterium as a proxy for hydrogen, atom probe tomography provides experimental evidence for interstitial hydrogen in solid solution across different FCC phases, consistent with theoretical predictions of hydrogen affinity, revealing hydrogen partitioning in structural alloys. Eason Yi-Sheng Chen Decoding the regulatory programs governing glioblastoma plasticity Multi-omic analyses of cells from patients with glioblastoma (GB) provide insight into the role of non-genetic cellular plasticity in disease progression, showing that state stability in GB cells is controlled by a network of interacting activators and repressors. Manu Saraswat Laura Rueda-Gensini Moritz Mall Article Open Access 04 Nov 2026 Decoding the regulatory programs governing glioblastoma plasticity Multi-omic analyses of cells from patients with glioblastoma (GB) provide insight into the role of non-genetic cellular plasticity in disease progression, showing that state stability in GB cells is controlled by a network of interacting activators and repressors. Laura Rueda-Gensini

Comprehensive mapping of essential-gene interactions in M. tuberculosis A high-throughput CRISPR-interference platform allows the mapping of interactions between essential genes in Mycobacterium tuberculosis , revealing many previously unknown genetic interactions and providing insight into gene function and drug–target relationships that could enable the development of new therapies for tuberculosis. Isaac J. Kresse Natalie Y. Sayegh Jeremy M. Rock Article Open Access 04 Nov 2026 Comprehensive mapping of essential-gene interactions in M. tuberculosis A high-throughput CRISPR-interference platform allows the mapping of interactions between essential genes in Mycobacterium tuberculosis , revealing many previously unknown genetic interactions and providing insight into gene function and drug–target relationships that could enable the development of new therapies for tuberculosis. Isaac J. Kresse Natalie Y. Sayegh Conjugation-regulated self-assembled molecules for tandem solar cells Rationally engineered molecular spatial conjugation is used for the formation of highly ordered, conformal self-assembled molecules, enabling the fabrication of high-performance perovskite/silicon tandem solar cells. Zheng Fang Zhijie Rao Xiaohong Zhang Article 04 Nov 2026 Conjugation-regulated self-assembled molecules for tandem solar cells Rationally engineered molecular spatial conjugation is used for the formation of highly ordered, conformal self-assembled molecules, enabling the fabrication of high-performance perovskite/silicon tandem solar cells. Hard X-ray attosecond metrology Metrology techniques are developed to characterize and control attosecond hard X-ray pulses, directly measuring a 170-attosecond duration and enabling ultrafast studies of electronic dynamics in quantum systems. Yanwen Sun River Robles Diling Zhu Article 04 Nov 2026 Hard X-ray attosecond metrology Metrology techniques are developed to characterize and control attosecond hard X-ray pulses, directly measuring a 170-attosecond duration and enabling ultrafast studies of electronic dynamics in quantum systems. Cancer-selective gene circuits via intrinsic ribosomal frameshifting Codon-pair-dependent ribosomal frameshifting is a feature of translational dysregulation in cancer cells. Qiuyi Wang Ao Chen Yuanhui Mao Article 04 Nov 2026 Cancer-selective gene circuits via intrinsic ribosomal frameshifting Codon-pair-dependent ribosomal frameshifting is a feature of translational dysregulation in cancer cells. Tracing the spread of Celtic languages using ancient genomics Genome-wide data from 4,587 ancient individuals are analysed, focusing on Bronze and Iron Age Europe, to test the extent to which alternative archaeological and linguistic models for the origin and spread of Celtic fit reconstructed demographic histories. Hugh McColl Guus Kroonen Eske Willerslev Article Open Access 04 Nov 2026 Tracing the spread of Celtic languages using ancient genomics Genome-wide data from 4,587 ancient individuals are analysed, focusing on Bronze and Iron Age Europe, to test the extent to which alternative archaeological and linguistic models for the origin and spread of Celtic fit reconstructed demographic histories. Eske Willerslev Venousization enables angiogenesis in the absence of VEGFR signalling Longitudinal tracking of endothelial cells shows they can adapt to loss of VEGFR2 and form new functional vessels, challenging conventional views of the essential role of VEGF receptors in angiogenesis and providing insight into resistance to anti-VEGF therapies. Irene Garcia-Gonzalez Susana F. Rocha Rui Benedito Article Open Access 04 Nov 2026 Venousization enables angiogenesis in the absence of VEGFR signalling Longitudinal tracking of endothelial cells shows they can adapt to loss of VEGFR2 and form new functional vessels, challenging conventional views of the essential role of VEGF receptors in angiogenesis and providing insight into resistance to anti-VEGF therapies. Irene Garcia-Gonzalez Susana F. Rocha The neural basis of flavour–nutrient learning A dopamine pathway to the basolateral amygdala is necessary for associating nutrients with flavours. James C. R. Grove Anna M. Hakimi Zachary A. Knight Article 04 Nov 2026 The neural basis of flavour–nutrient learning A dopamine pathway to the basolateral amygdala is necessary for associating nutrients with flavours. James C. R. Grove Zachary A. Knight Nectin-4 mediates rubella virus entry in airway and placental cells Nectin-4 is identified as a pivotal host entry receptor for respiratory transmission and early placental infection of rubella virus. Yoshio Mori Masafumi Sakata Akihide Ryo Article 04 Nov 2026 Nectin-4 mediates rubella virus entry in airway and placental cells Nectin-4 is identified as a pivotal host entry receptor for respiratory transmission and early placental infection of rubella virus. Masafumi Sakata Aggression experience and observation drive shared behavioural and neural changes Aggression experience and observation recruit a brain-wide network of excitatory, inhibitory and valence signals, and changes to this activation pattern predict a shared adaptive behaviour-control policy in a new aggression context. Jorge M. Iravedra-García Eartha Mae Guthman Annegret L. Falkner Article Open Access 04 Nov 2026 Aggression experience and observation drive shared behavioural and neural changes Aggression experience and observation recruit a brain-wide network of excitatory, inhibitory and valence signals, and changes to this activation pattern predict a shared adaptive behaviour-control policy in a new aggression context. Jorge M. Iravedra-García Eartha Mae Guthman Annegret L. Falkner Explore articles by subject Guide to authors Editorial policies